Structural Biologist · Biophysicist
Structural Biophysics | Oncology & Antibody Protein Engineering | AI Protein Tools & MD | SAXS, NMR, SPR & AUC
Integrative structural biologist and biophysicist with deep expertise in drug discovery support, biophysical characterisation, and structural analysis of immune receptors and glycoproteins. Passionate about bridging rigorous science with translational impact.
Profile
I am an integrative structural biologist and biophysicist with over 6 years of rigorous, hands-on expertise in delivering high-impact drug discovery support through expert biophysical characterisation, strategic project leadership, and stakeholder collaboration.
My work spans oncology, immunology, and therapeutic antibody/nanobody targets, applying a multi-platform biophysical approach (SPR, ITC, SEC-MALS, NMR, SAXS/SANS, AUC) to solve challenging structural and binding problems. I am equally comfortable leading complex projects end-to-end and mentoring the next generation of researchers.
During my time as a Research Fellow at the University of Birmingham, I led biophysics and bioprocess development for a critical oncology programme, elucidating the conformational dynamics of the KRAS molecular switch using multi-dimensional NMR (HSQC, CPMG, CEST) and developing robust purification protocols for labile membrane-associated signalling proteins.
I believe that good structural biology is as much about communication and collaboration as it is about technique — and I strive to bring both to every project I join.
What I work on
Combining NMR, SAXS/SANS, X-ray crystallography, and computational modelling with quantitative biophysical methods — SPR, ITC, SEC-MALS, AUC, DLS, and thermal shift assays — to reveal protein structure, dynamics, and binding interactions at atomic resolution for drug discovery.
Structural and functional analysis of Fc receptors, complement proteins, and nanobody therapeutics, with a focus on how N-linked glycosylation shapes protein self-association, immune regulation, and therapeutic efficacy across oncology and autoimmune disease targets.
End-to-end biophysical support for oncology and immunology programmes — from antigen characterisation to therapeutic validation. Includes multi-dimensional NMR (HSQC, CPMG, CEST) investigation of the KRAS molecular switch, providing mechanistic frameworks applicable to Rho/Rac GTPase targets.
Research spanning from rare autoimmune disease to COVID-19 therapeutics and oncology — characterising a diverse range of clinically relevant proteins.
Integrating machine learning and molecular simulation with experimental biophysics to accelerate structure-function understanding.
Peer-reviewed work
Academic background
Technical expertise
Scientific community
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